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Season guide

House: Season 5

24 episodes Premiered Sep 16, 2008 Updated Oct 1, 2026

House Season 5 continues the overarching saga across 24 episodes. The series features Dr. Gregory House, who is a drug-addicted, unconventional, misanthropic medical genius leading a team of diagnosticians. The American medical drama television series, created by David Shore, also features cast members including Hugh Laurie, Omar Epps, Robert Sean Leonard, and Jesse Spencer. The program originally aired on the Fox ne

Previously on House

Season 5 Lore Primer

Key plot threads, lore context, and character stakes you need to remember before diving into this season.

  • ⚡ Dr. Gregory House is a drug-addicted, unconventional, misanthropic medical genius.
  • ⚡ House leads a team of diagnosticians.
  • ⚡ The series was created by David Shore.
  • ⚡ The show features cast members including Hugh Laurie, Omar Epps, Robert Sean Leonard, and Jesse Spencer.
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Season overview

House Season 5 continues the overarching saga across 24 episodes. The series features Dr. Gregory House, who is a drug-addicted, unconventional, misanthropic medical genius leading a team of diagnosticians. The American medical drama television series, created by David Shore, also features cast members including Hugh Laurie, Omar Epps, Robert Sean Leonard, and Jesse Spencer. The program originally aired on the Fox network and was broadcast for eight seasons beginning in 2004.

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Season 5 Episodes

Episode Guide

🛡️ SPOILER SHIELD

Season 5 Progress Shield

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Binge Efficiency Engine

Season 5: Filler vs. Essential Canon

Filter episodes by narrative weight. Focus on essential mytharc and skip standalone side quests.

13%
88%
Mytharc (3): Crucial lore & season climaxes
Core (21): Character development & subplots
Side Quest (0): Standalone / filler
S5·E1 Mytharc

Dying Changes Everything

Sep 16, 2008 · 44 min

In the aftermath of personal tragedy, Wilson resigns from the hospital... and from his friendship with House. Meanwhile, Thirteen struggles with her personal medical problems while

S5·E2 Core

Not Cancer

Sep 23, 2008 · 44 min

The team deals with an organ donor whose organs prove fatal, and the two surviving patients. Meanwhile, House hires a private detective to spy on Wilson, but hears a few things abo

S5·E3 Core

Adverse Events

Sep 30, 2008 · 44 min

A painter's undiagnosed illness affects his work, and House and his team must look at the man's paintings to determine what's wrong with him.

S5·E4 Core

Birthmarks

Oct 14, 2008 · 44 min

While en route to his father's funeral, House must help the team with a differential diagnosis on a young Chinese girl who has collapsed under mysterious circumstances.

S5·E5 Core

Lucky Thirteen

Oct 21, 2008 · 44 min

Thirteen brings her one-night stand to the hospital after the woman has a seizure. However, the woman admits she slept with Thirteen just so she could get to House and have him dia

S5·E6 Core

Joy

Oct 28, 2008 · 44 min

An ailing man suffers from blackouts and sleepwalks, leading the team to wonder if his sleepwalking is a symptom, or how the man is becoming exposed to something else. When the man

S5·E7 Core

The Itch

Nov 11, 2008 · 44 min

The team must treat an agoraphobic who refuses to leave his house, and have to work around Cuddy, who is less than thrilled at having hospital equipment relocated. Meanwhile, House

S5·E8 Core

Emancipation

Nov 18, 2008 · 44 min

While Foreman takes on a pediatric case on his own, the rest of the team deals with a 16-year-old factory manager and emancipated minor who collapses at work. When Foreman's patien

S5·E9 Core

Last Resort

Nov 25, 2008 · 43 min

A gun-wielding man from the waiting room at the Princeton-Plainsboro clinic takes House, Thirteen and several patients from the waiting room hostage in Cuddy's office. The man clai

S5·E10 Core

Let Them Eat Cake

Dec 2, 2008 · 44 min

The team takes on the case of a fitness guru on an all-natural diet who collapsed while filming a video. Meanwhile, Foreman conducts Huntington's Disease drug trials and Thirteen s

S5·E11 Core

Joy to the World

Dec 9, 2008 · 44 min

House and his team deal with a bullied girl who collapses during her school's Christmas program. Meanwhile, Foreman and Thirteen grow closer during the Huntington's disease drug tr

S5·E12 Core

Painless

Jan 19, 2009 · 44 min

House and the team try to diagnose a man living with severe, chronic pain; Thirteen and Foreman explore their complicated relationship; Cuddy discovers that caring for her baby lea

S5·E13 Core

Big Baby

Jan 26, 2009 · 44 min

Cuddy decides to spend more time at home to take care of her newly adopted baby and passes some of her day-to-day responsibilities off to Cameron, including supervising House. Came

S5·E14 Core

The Greater Good

Feb 2, 2009 · 44 min

House and the team take on the case of a woman who collapsed in the middle of a cooking class, and they soon learn she is a highly-renowned cancer researcher who recently gave up h

S5·E15 Core

Unfaithful

Feb 16, 2009 · 44 min

When a priest who runs a homeless shelter sees a bleeding Jesus hovering at his doorstep, he is admitted to the ER. House takes on the case as a distraction for the team while he c

S5·E16 Core

The Softer Side

Feb 23, 2009 · 44 min

A patient with both male and female DNA has the team stumped. Meanwhile, House starts acting nicely, raising Cuddy's and Wilson's suspicions that something is terribly wrong.

S5·E17 Core

The Social Contract

Mar 9, 2009 · 44 min

House and the team take on the case of Nick, a book editor who loses his inhibitions. The team realizes Nick has frontal lobe disinhibition, which causes him to speak his mind havi

S5·E18 Core

Here Kitty

Mar 16, 2009 · 44 min

Morgan works in a nursing home with a pet cat who only sleeps next to people if they are about to die - and does so with alarmingly accuracy. When it seems the cat has predicted he

S5·E19 Core

Locked In

Mar 30, 2009 · 44 min

A man awakens in New York after a bicycle accident unable to move or communicate in any way. House, himself injured in a motorcycle mishap, occupies the hospital bed next to Lee an

S5·E20 Core

Simple Explanation

Apr 6, 2009 · 44 min

Charlotte, an older woman who has spent the last six months taking care of her dying husband Eddie, is rushed to Princeton Plainsboro after collapsing from respiratory failure. The

S5·E21 Core

Saviors

Apr 13, 2009 · 44 min

Cameron postpones her vacation with Chase in order to ask House to accept the case of an environmental radical who collapsed at a protest with unexplainable symptoms. Although susp

S5·E22 Core

House Divided

Apr 27, 2009 · 44 min

The team takes on the case of a deaf 14-year-old named Seth who collapsed after he started “hearing” explosions while competing in a wrestling match. When the team tries to test hi

S5·E23 Mytharc

Under My Skin

May 4, 2009 · 44 min

House and the team take on the case of a ballerina whose lungs collapse in the middle of a performance. When the treatment causes her skin to fall off, the dancer faces not only th

S5·E24 Mytharc

Both Sides Now

May 11, 2009 · 44 min

House and the team are intrigued by Scott, a man whose left brain and right brain operate independently, leaving him with two distinct personalities and no control over some of his

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