S1·E23 The Sound of Rust

In a cold mountainous region, Ginko is wandering around the snow cover plain when he hears a sound ringing through the cold air and he also notices some rust on a tree. Ginko enters a nearby town to find the rust covering everywhere, including the people. The village chief tells Ginko that this is a sickness that has been affecting the town for 14 years that the people have been slowly losing the movements of the limbs and it's said that a girl called Shige is the cause of it.