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Season guide

House: Season 4

16 episodes Premiered Sep 25, 2007 Updated Oct 1, 2026

House Season 4 continues the overarching saga across 16 episodes. Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional hospital setting established in the series created by David Shore. The show stars Hugh Laurie alongside cast members such as Omar Epps, Robert Sean Leonard, and Jesse Spencer. The medical drama series originally aired on the

Previously on House

Season 4 Lore Primer

Key plot threads, lore context, and character stakes you need to remember before diving into this season.

  • ⚡ Dr. Gregory House is established as a drug-addicted, unconventional, and misanthropic medical genius.
  • ⚡ House leads a team of diagnosticians handling complex medical cases.
  • ⚡ The series features characters portrayed by actors including Hugh Laurie, Omar Epps, Robert Sean Leonard, and Jesse Spencer.
  • ⚡ The American medical drama series was created by David Shore and originally broadcast on the Fox network.
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Season overview

House Season 4 continues the overarching saga across 16 episodes. Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional hospital setting established in the series created by David Shore. The show stars Hugh Laurie alongside cast members such as Omar Epps, Robert Sean Leonard, and Jesse Spencer. The medical drama series originally aired on the Fox network across eight seasons from November 16, 2004, until May 21, 2012. As part of the ongoing narrative, the medical genius character applies his unconventional methods and diagnostic skills alongside his team to address complex medical cases presented throughout the sixteen episodes of this fourth season.

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Season 4 Episodes

Episode Guide

🛡️ SPOILER SHIELD

Season 4 Progress Shield

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Binge Efficiency Engine

Season 4: Filler vs. Essential Canon

Filter episodes by narrative weight. Focus on essential mytharc and skip standalone side quests.

19%
81%
Mytharc (3): Crucial lore & season climaxes
Core (13): Character development & subplots
Side Quest (0): Standalone / filler
S4·E1 Mytharc

Alone

Sep 25, 2007 · 44 min

With his diagnostic team gone, House tries to diagnose a young woman who survived an office building collapse. With the condition getting worse, Cuddy puts pressure on House to hir

S4·E2 Core

The Right Stuff

Oct 2, 2007 · 44 min

House is secretly trying to treat a fighter pilot who is a candidate for NASA's astronaut training program. Her diagnosis will be the test to choose which ones of the 40 applicants

S4·E3 Core

97 Seconds

Oct 9, 2007 · 44 min

The candidates are now two teams of five women and five men, competing on diagnosing and treating a wheelchair-bound man. Meanwhile House does experiments on himself to test what h

S4·E4 Core

Guardian Angels

Oct 23, 2007 · 44 min

House finds that some of his own fellowship students will do whatever it takes, when they deal with a woman who believes she can talk to the dead.

S4·E5 Core

Mirror Mirror

Oct 30, 2007 · 44 min

House deals with a patient who mirrors the personality of anyone he meets. Meanwhile, Foreman is put in charge of overseeing the fellowship candidates.

S4·E6 Core

Whatever It Takes

Nov 6, 2007 · 44 min

Based on practically no information and no medical history about a mystery patient sent by the CIA, House is using some unorthodox methods to diagnose and treat him. Meanwhile the

S4·E7 Core

Ugly

Nov 13, 2007 · 44 min

A film crew and the candidates are following around House distracting him while he is trying to diagnose a teenager who suffers from a heart attack prior to a serious plastic surge

S4·E8 Core

You Don't Want to Know

Nov 20, 2007 · 44 min

House treats a magician but comes to believe he's faking illness to cover up his own incompetence. Meanwhile, House pits the fellows against each other in his version of an immunit

S4·E9 Core

Games

Nov 27, 2007 · 44 min

Under Cuddy’s pressure to choose his team, House gives the candidates a case of a former punk rock star who is a drug user. Whoever diagnoses the patient is going to have a future

S4·E10 Core

It's a Wonderful Lie

Jan 29, 2008 · 44 min

A mother's sudden paralysis during a indoor rock-climbing incident leaves her daughter injured, and House's new team looking for a cure. Meanwhile, House organizes his new recruits

S4·E11 Core

Frozen

Feb 3, 2008 · 44 min

House and his team have to diagnose a case at a distance when a researcher at a South Pole base is taken ill.

S4·E12 Core

Don't Ever Change

Feb 5, 2008 · 44 min

House and his team must diagnose a Jewish bride who is taken ill at her wedding. However, House is more interested in analyzing Wilson's relationship with his new girlfriend.

S4·E13 Core

No More Mr. Nice Guy

Apr 28, 2008 · 44 min

House copes with a patient whose symptoms conceal a greater problem, but spends much of his time dodging Cuddy's orders to give performance reviews, and fighting with Amber over wh

S4·E14 Core

Living the Dream

May 5, 2008 · 44 min

House is convinced one of the actors on his favorite soap opera “Prescription Passion” has a serious medical condition after observing his symptoms on television. House decides to

S4·E15 Mytharc

House's Head (1)

May 12, 2008 · 44 min

A bus accident leaves House with serious head trauma and partial amnesia. He comes to believe that a patient on the bus had a life-threatening disease and struggles to recall who i

S4·E16 Mytharc

Wilson's Heart (2)

May 19, 2008 · 44 min

In the aftermath of the bus accident, House struggles with his head injuries and short-term memory loss, and must deal with a concerned Wilson who believes his friend's health may

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