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Season guide

Grey's Anatomy: Season 1

9 episodes Premiered Mar 27, 2005 Updated Jul 18, 2026

The first season of the American medical drama Grey's Anatomy introduces Meredith Grey, the daughter of the renowned surgeon Ellis Grey, as she begins her career as an intern at Seattle Grace Hospital. During the intern program, Meredith forms close friendships with fellow interns Cristina Yang, Isobel Stevens, George O'Malley, and Alex Karev. Throughout their training, the group works under the supervision of their

Season overview

The first season of the American medical drama Grey's Anatomy introduces Meredith Grey, the daughter of the renowned surgeon Ellis Grey, as she begins her career as an intern at Seattle Grace Hospital. During the intern program, Meredith forms close friendships with fellow interns Cristina Yang, Isobel Stevens, George O'Malley, and Alex Karev. Throughout their training, the group works under the supervision of their resident, Dr. Miranda Bailey, who is also known as The Nazi. The interns also interact with established medical professionals at the hospital, including the chief of surgery Richard Webber, who is an old friend of Meredith's mother, and the heart surgeon Preston Burke. Additionally, Meredith navigates a complex professional relationship with neurosurgeon Derek Shepherd, with whom she previously had a one-night stand. Created by Shonda Rhimes, the series focuses on the personal and professional lives of these surgical interns and their supervisors. The show debuted on ABC in 2005, establishing the setting of the fictional Seattle Grace Hospital where the medical staff balances the demands of their careers with their private lives.

Episodes

S1·E1

A Hard Day's Night

Mar 27, 2005 · 43 min

Meet Meredith Grey. Daughter of famous surgeon Ellis Grey and currently recovering from a one-night stand. She shoos away her evening's companion, saying she'll be late for her fir

S1·E2

The First Cut is the Deepest

Apr 3, 2005 · 43 min

The surgical staff tries to be optimistic as a young woman clings to life after a brutal attack. Meanwhile Meredith puts her career on the line to save a newborn in the hospital nu

S1·E3

Winning a Battle, Losing the War

Apr 10, 2005 · 43 min

A bike race injures several pedestrians as well as well as participants. One pedestrian is left brain dead. Christina and Issie wish to use his organs for organ donation but with

S1·E4

No Man's Land

Apr 17, 2005 · 43 min

While George is feeling a little less masculine because of the way Izzie and Meredith have been treating him (like a sister), Izzie is assigned to a patient about to loose all of h

S1·E5

Shake Your Groove Thing

Apr 24, 2005 · 43 min

Meredith realizes that she must take on a lot more responsibility when she is told that her mother needs to sign over all of her assets to her. As Izzie prepares to have a party fo

S1·E6

If Tomorrow Never Comes

May 1, 2005 · 43 min

Izzie tries to get George to find the courage to ask Meredith out. All of the interns are in awe when a woman comes in with a record breaking tumor, but it is so far advanced tha

S1·E7

The Self-Destruct Button

May 8, 2005 · 43 min

Derek and Meredith try (unsuccessfully) to be discreet as they spend the night together at Meredith's house, but their haggard appearance speaks volumes to everyone - including Bai

S1·E8

Save Me

May 15, 2005 · 43 min

Meredith grows increasingly dissatisfied with the unknown details of Derek's life. Meanwhile, Alex treats Devo, a patient whose religious beliefs jeopardize her chances for recover

S1·E9

Who's Zoomin' Who?

May 22, 2005 · 43 min

A sexually transmitted disease breaks out and affects several members of the hospital staff. Chief Webber promptly calls a meeting. Meanwhile, the chief reluctantly tells Dr. Derek