Home health Even taking immunosuppressants after organ transplantation has no effect on gastric cancer surgery

Even taking immunosuppressants after organ transplantation has no effect on gastric cancer surgery

by drbyos

A study found that taking immunosuppressants after organ transplantation had little effect on gastric cancer surgery.

A research team led by Professor Kim Hyung-il of Gastrointestinal Surgery at Yonsei Cancer Hospital and Professor Kim Deok-gi of Wonju Severance Christian Hospital in Transplant Surgery analyzed the incidence of complications between patients who underwent gastric cancer surgery while taking immunosuppressants after organ transplantation and patients with general gastric cancer.

Organ transplant patients who usually take immunosuppressants are often concerned that the risk of complications and infection is high if the immune system is weakened by excision of cancer tissue or administration of chemotherapy.

The research team compared and analyzed the surgical results of 41 patients (35 kidney transplants, 5 liver transplants, 1 heart transplant) who underwent gastric cancer surgery after organ transplantation and 205 general gastric cancer patients with similar conditions such as gender and age. .

As a result, the short-term complication rate within 30 days after gastrectomy was 22.0% for transplant patients and 20.0% for control patients.

The rate of long-term complications 30 days after gastrectomy was 4.9% for transplant patients and 1.0% for controls, and there was no significant difference.

There was no significant difference in the results of tracking the cancer recurrence rate for 58 months after that, with 20.0% in the transplant patient group and 19.0% in the control group.

The research team explained that there was no significant difference in the incidence of long-term and short-term complications between transplant patients and general patients.

However, in a 58-month follow-up study on the recurrence rate, 26 organ transplant patients with stage 1 stomach cancer did not have cancer recurrence, but 15 organ transplant patients with stage 2 or 3 stomach cancer had a recurrence rate of 75%, twice that of general patients.

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In this study, the research team pointed to the fact that the rate of anticancer drug administration in organ transplant patients with stage 2 or 3 stomach cancer was significantly low.

Their anticancer drug administration rate was 26.6%, which was significantly lower than the general patient’s anticancer drug administration rate of 95.8%.

The research team interpreted these results as reluctance to administer anticancer drugs because of anxiety that anticancer drugs could cause side effects to transplanted organs.

Professor Kim Hyung-il said, “This study has made it possible for organ transplant patients to lessen concerns about complications from gastric cancer surgery. “The patient should be actively receiving chemotherapy,” he said.

The research results were published in the latest issue of the European Journal of Surgical Oncology, an international academic journal.

Kwon Dae-ik medical journalist




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