Home health Diabetes increases the risk of severe form of Covid-19 mainly in young adults: conclusion of a study from the AP-HP health data warehouse

Diabetes increases the risk of severe form of Covid-19 mainly in young adults: conclusion of a study from the AP-HP health data warehouse

by drbyos

Work carried out by diabetology teams from AP-HP hospitals, the Cordeliers Research Center, Inserm and the University of Paris, coordinated by Dr Marc Diedisheim from Cochin hospital and Dr Louis Potier from Bichat – Claude-Bernard Hospital, compared the risk of death or orotracheal intubation between patients with or without diabetes hospitalized for Covid-19. They were the subject of a publication in the journal The Journal of Clinical Endocrinology & Metabolism 1is June 2021.

From the start of the SARS-Cov-2 epidemic, patients suffering from diabetes, a common disease that affects people of varying ages, were identified as being among the most at risk of developing a severe form of Covid- 19. However, the available data did not allow us to know whether the risk was the same for all age categories.

This observational study was based on data from AP-HP Health Data Warehouse. It involved 6,314 patients hospitalized for Covid-19 at AP-HP between February and June 2020. Its objective was to study the risk of developing a severe form of Covid-19 (requiring intubation or leading to death ) by age in patients hospitalized for Covid-19 with or without diabetes. Diabetes was present in 39% of patients.

The results of the study show that diabetes increases the risk of a severe form of COVID more significantly in adults with diabetes under the age of 70. Indeed, the risk of intubation or death increases progressively with age (23% risk for those under 50 and 35% for those over 80) for all patients. However, the risk is significantly higher in diabetics than in non-diabetics up to the age of 70. After this age, the risk of developing a severe form of the disease for diabetics decreases, reaches a plateau and reaches a rate comparable to that of non-diabetic patients of the same age category (over 80 years).

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Reference: Diabetes increases severe COVID-19 outcomes primarily in younger adults Age and diabetes in COVID-19 severity

Marc Diedisheim, Etienne Dancoisne, Jean-François Gautier, Etienne Larger, Emmanuel Cosson, Bruno Fève, Philippe Chanson, Sébastien Czernichow, Sopio Tatulashvili, Marie-Laure Raffin-Sanson, Kankoé Sallah, Muriel Bourgeon, Christiane Ajzenberg, Agnès Hartemann, Christel Daniel , Thomas Moreau, Ronan Roussel, Louis Potier

DOI : https://doi.org/10.1210/clinem/dgab393

About University of Paris : University of intensive multidisciplinary research, the University of Paris has risen to the level of the most prestigious French and international institutions thanks to its very high-level research, its superior higher education, its support for innovation and its active participation in construction of the European research and training area.

University of Paris has 63,000 students, 7,500 teacher-researchers and researchers, 21 doctoral schools and 126 research laboratories. Visit u-paris.fr.

About the AP-HP: First hospital and university center (CHU) in Europe, the AP-HP and its 39 hospitals are organized into six university hospital groups (AP-HP. Center – University of Paris; AP-HP. Sorbonne University; AP-HP . North – University of Paris; AP-HP. Paris Saclay University; AP-HP. Henri Mondor and AP-HP University Hospitals. Paris Seine-Saint-Denis University Hospitals) and are organized around five universities in the Ile-de-France region. Closely linked to major research organizations, the AP-HP has three world-class hospital-university institutes (ICM, ICAN, IMAGINE) and the largest French health data warehouse (EDS). A major player in applied research and innovation in health, the AP-HP holds a portfolio of 650 active patents, its clinician-researchers sign nearly 9,000 scientific publications each year and more than 4,000 research projects are currently in progress. development course, all promoters combined. In 2020, AP-HP obtained the Institut Carnot label, which rewards the quality of research partnership: Carnot @ AP-HP offers industrial players solutions in applied and clinical research in the field of health. The AP-HP also created in 2015 the AP-HP Foundation for Research to support biomedical and health research carried out in all of its hospitals. http://www.aphp.fr

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